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KMID : 0380319920500000125
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Journal of Korean Research Institute for Better Living
1992 Volume.50 No. 0 p.125 ~ p.130
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The Long QT Interval in Diabetic Patients
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Abstract
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A long QT interval in diabetic patients is attributed to autonomic neuropathy and is thought to predispose to arrhythmias and sudden death. Measurement of the QTc interval in resting electrocardiography in patients with diabetes mellitus may be a simple method for assessment of alterations in cardiac autonomic innervation.
Author studied the value of resting corrected QT interval by Bazzatt´s formula (QTc) as a marker of cardiac autonomic neuropathy(CAN) in patients with DM and relationship between a long QTc interval and arrhythmia.
Sixty patients with DM(52 with NIDDM, and 8 with IDDM) underwent cardiac autonomic function tests(resting heart rate, heart rate response to standing, deep breathing and Valsalva maneuver and blood pressure response to standing) and had ambulatory electrocardiographic monitoring for 24 hours.
The results were as follows,
1) The QTc interval of diabetic patients was significantly prolonged than that of control subjects(p＜0.05).
2) Thirty-six diabetic patients had a long QTc interval(＞435 msec), and of the patients with long QTc interval, 30(83.3％) had one or more abnormal CAN score compared with 7(29.2％) of those with normal QTc interval.
3) The direct linear relationship between QTc interval and extent of cardiac autonomic neuropathy represented by cardiac autonomic function score was found(r=0,53, p＜0.05).
4) Diabetic patients with long QTc interval had significantly longer duration of DM than those with normal QTc interval(p＜0.05).
5) Ambulatory electrocardiographic monitoring revealed no significant ventricular arrhythmia in diabetic patients with or without long QTc interval.
In conclusion, The QTc interval was an additional non-invasive diagnostic tool in the assessment of CAN in diabetic patients, and these data did not demonstrate a potential arrhythmogenic effect of long QT interval.
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KEYWORD
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